The AXIMA Performance is one of the most powerful tools in mass
spectrometry, delivering information-rich spectra with greater
sensitivity and higher confidence in identification. Extremely
versatile, this MALDI TOF-TOF mass spectrometer utilizes
state-of-the-art high energy MS/MS, delivers unparalleled
flexibility in an ergonomic, robust and reliable research-grade
system, and provides the pinnacle of performance for high-energy
MS/MS interrogation of proteomics, biological and organic samples.
Features
Highest Energy Collisions
A CID with a laboratory frame collisional energy of 20keV delivers
true high-energy MS/MS and, together with the newly redesigned
curved field reflectron, produces well-balanced, information-rich
MS/MS data.
The novel additional LMZ scan allows focus of the analysis to be
directed around the low mass region of the MS/MS spectrum.
Revolutionary Gating Technology
Allows optimal isolation of precursor ions with market-leading
optimal precursor ion selection (>400 resolution FWHM),
preventing the complication of overlapping fragmentation spectra
from analytes with similar nominal masses. The resulting MS/MS
spectra are easier to interpret and significant database search
hits are more readily achieved.
High Sensitivity/Resolution
Near axis laser irradiation provides enhanced ion transmission and
sensitivity in all modes of operation. The unique reflectron design
improves resolution, and enhanced calibration algorithms with
easy-to-use software provide more accurate data.
Outstanding Sensitivity with an uncompromised gridless design that ensures no MS/MS signal
is lost.
High-resolution MS Data in Reflectron Mode
At >20,000 FWHM, the AXIMA Performance enables more accurate and
confident peptide mass fingerprinting.
Uncompromised Linear Mass Range and Sensitivity
A highly optimized linear mode generates reproducible and sensitive
results for very high mass compounds and complexes, extending the
array of sample classes that may be analyzed.
Low Sample Consumption allows many more MS/MS experiments to be performed on the same
sample spot.
Unparalleled Flexibility
Not just another proteomics workhorse, polymers, oligonucleotides,
SNPs, metabolites, carbohydrates and small molecules, among others,
may all be analyzed and processed. A variety of sample target
formats, including standard microtiter plate format 96 or 384 well
targets, can be used.
Seamless Integration with Other Instruments
Like all AXIMA MALDI-TOF systems, the AXIMA Performance can be
fully integrated with robotic sample preparation devices, including
the AccuSpot MALDI plate spotter and CHIP chemical printer, to
create application-specific platforms. Integration with the CHIP
creates a powerful platform for tissue imaging, while using an
AXIMA instrument with a Prominence GPC system and AccuSpot results
in a fully automated platform for polymer analysis that delivers
quick, detailed analysis of ultra-trace substances.
The AXIMA Performance is fully integrated with AnagnosTec’s SARAMIS
databases for rapid and accurate microorganism identification. This
AXIMA@SARAMIS platform is an easy-to-use Microbial Identification
System. The Performance can also be combined with various
fractionation/enrichment chemistries and Nonlinear Dynamic’s
Progenesis biomarker software for a complete biomarker discovery
solution.
Software
Intuitive software incorporating data-dependent workflows
facilitates the seamless analysis of as few or as many samples as
required and achieves the maximum result with minimal user input,
making it ideal for novice and expert users alike.
Application-centric data processing software packages are available
to provide solutions to many commonly asked questions. These
include:
- Proteomics From single sample manual acquisition to fully automated
data-dependent peptide mass fingerprinting and MS/MS for protein
identification with integrated Mascot searching
- LC-MALDI Allows the fully automated acquisition of LC separated samples
deposited onto MALDI targets and the subsequent identification of
proteins via MS/MS of the peptides detected
- Polymers Enables rigorous interrogation of polymer-derived data sets, and
unique copolymer software provides valuable insight into the
composition of copolymers comprised of two or more monomeric
distributions
- Biomarker DiscoveryTissue Imaging Allows the recognition of biomarker patt
